Researchers Evaluate Stonebreaker's Immunity-Boosting Effects

The human immune system is a powerful network designed to protect us from illnesses and infections. It consists of various immune cells and molecules that work together to recognize and destroy harmful invaders, such as viruses and bacteria. In recent years, immunomodulators—substances that help balance immune responses—have gained attention. These compounds support immune health by activating or calming different parts of the immune system, as needed.

Phyllanthus niruri, commonly known as stonebreaker, shows strong potential as an immunomodulator. Traditionally used in tropical regions for its medicinal properties, it has been applied in indigenous medicine to address immune-related health concerns.¹ Current research focuses on understanding how stonebreaker may support immune responses when the body is combating various infections.

The Study

To study the effects of stonebreaker on the immune system, researchers examined its bioactive compounds, which include flavonoids, lignans, and terpenoids. These compounds are known for their health benefits, and studies aimed to see how they impact both innate immunity (the body's immediate response to threats) and adaptive immunity (the system's learned response to specific pathogens).

The extensive scientific review they conducted covered seven studies over an 18-year period, including human trials, laboratory studies, and other research types. The review examined how stonebreaker affects immune function, from cell activation processes to potential antiviral effects.

The Results

The results were promising across all reviewed publications. In human studies, stonebreaker extract showed antiviral activity, particularly in reducing HIV-1 replication. This finding is significant, as it suggests that stonebreaker may be able to fight viruses selectively, targeting them without harming healthy cells. Researchers found that repandusinic acid, a compound in stonebreaker, effectively inhibited the virus while leaving healthy cells intact.

Laboratory studies showed that stonebreaker could increase the activity of essential immune cells like T and B lymphocytes. It also enhanced the function of dendritic cells, which help the immune system recognize pathogens. Stonebreaker extract stimulated the production of nitric oxide, a molecule that aids in immune defense by targeting pathogens.

Published animal studies provided additional support for stonebreaker's immunity-enhancing benefits. The herb has been shown to increase immune regulation, including a boost in cytokine release. Cytokines are molecules that help control immune cell activity, and higher cytokine levels indicate a stronger immune response. Additionally, stonebreaker improved macrophage activity. Macrophages are immune cells that consume and break down harmful particles in the body, which is crucial for fighting infections.

What Does This Mean?

Published in the International Journal of Pharmaceutical Chemistry and Analysis, the study highlights stonebreaker's potential as a natural aid to support immune function. Its bioactive compounds not only support immune cell activity but also exhibit antiviral properties that may be beneficial in managing viral infections and could contribute to the development of antiviral therapies.

In addition to its antiviral effects, stonebreaker enhances immune cell responses, promoting faster recognition and elimination of pathogens. This could make it a helpful supplement for people seeking to boost their immune defenses, especially those with weakened immune systems or who are exposed to frequent infections.

While more research is necessary to confirm these effects in larger populations, the findings suggest that stonebreaker holds promise as a natural immunomodulator. Other herbs that offer similar benefits include astragalus, soursop, garlic, and camu camu.